Hox Genes, a Molecular Constraint for the Development and Evolution of the Vertebrate Body Plan

DOI 2 Citations 52 References
  • Iimura Tadahiro
    Global Center of Excellence Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University Sections of Oral Pathology, Tokyo Medical and Dental University
  • Himeno Akiko
    Global Center of Excellence Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University Sections of Oral Pathology, Tokyo Medical and Dental University Sections of Periodontology, Tokyo Medical and Dental University
  • Nakane Ayako
    Global Center of Excellence Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University Sections of Oral Pathology, Tokyo Medical and Dental University Sections of Pediatric Dentistry, Tokyo Medical and Dental University
  • Yamaguchi Akira
    Global Center of Excellence Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University Sections of Oral Pathology, Tokyo Medical and Dental University

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Abstract

A set of Hox genes expressed during the embryonic process presents a crucial system to set up the body plan in animal phyla. Current systematic approaches, such as bio-imaging, epigenetic regulation and phylogenetic genome comparison, illuminated new comprehensive insights into Hox genes as an evolutionary constraint of the vertebrate body plan, which provides a novel counter-view to give further insights into the evolution and development of the craniofacial and dental systems as non-Hox systems.

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