Fine Structural Analysis of Bioactive Porous Ceramics using Microcomputed Tomography (μCT)

• Nakayama Hitoshi

  Japan Science and Technology Agency Innovation Satellite Niigata Division of Oral Bioengineering, Department of Tissue Regeneration and Reconstitution, Institute of Medicine and Dentistry, Niigata University

• Kawase Tomoyuki

  Division of Oral Bioengineering, Department of Tissue Regeneration and Reconstitution, Institute of Medicine and Dentistry, Niigata University

Bibliographic Information

Other Title

• X線マイクロCTによる生体活性セラミックス多孔体の微小構造解析

Abstract

Porous ceramics have increasingly been applied as a biocompatible bone substitute to fill bone defects in orthopedic and other bone regenerative medicine. To characterize these biomaterials using microfocus-computed tomography (μCT) in this study, we tested the tentative protocols proposed by the working committee of the Ministry of Economy, Trade and Industry of Japan. Six commercial bioceramics (φ5×10 mm) were analyzed with high or medium resolution. After 3-D reconstruction, pore distribution and total porosity were calculated in each sample. With medium resolution [FOV (XY plane): 2.8-3.0 mm, 512 pixels], our μCT easily and accurately acquired interior images without destruction of the sample. Except for two samples, in which major pores were not equally distributed, very similar data were obtained in the remaining of samples by four independent observers who employed different types of μCT or image-analysis software. More than 80% of pores appeared to form pore-complexes that were well interconnected with each other. Since these data were confirmed by other methodologies using a scanning electron microscopy (SEM) and an Hg porosimeter, it is suggested that the committee's protocol could be appropriate for using μCT to accurately characterize the microstructure of porous ceramics by a nondestructive method.

Journal

• Shika Hoshasen

  Shika Hoshasen 49 (3), 33-40, 2009

  Japanese Society for Oral and Maxillofacial Radiology

Keywords

• Bioactive ceramics
• Porosity
• Microstructure
• Bone substitute
• Micro CT

Details

• CRID: 1390282679938452992
• NII Article ID: 130004912395
• NII Article ID: 10027301009
• NII Book ID: AN00101479
• DOI: 10.11242/dentalradiology.49.33
• ISSN: 21856311
• ISSN: 03899705
• Web Site: https://search.jamas.or.jp/link/ui/2010180403
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed