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- KINOSHITA Mika
- Graduate School of Bioagricultural Sciences, Nagoya University
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- I'ANSON Helen
- Biology Department, Washington and Lee University
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- TSUKAMURA Hiroko
- Graduate School of Bioagricultural Sciences, Nagoya University
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- MAEDA Kei-ichiro
- Graduate School of Bioagricultural Sciences, Nagoya University
書誌事項
- タイトル別名
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- Fourth Ventricular Alloxan Injection Suppresses Pulsatile Luteinizing Hormone Release in Female Rats
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抄録
Previous studies have suggested the presence of a glucose-sensing mechanism in the hindbrain that appears to regulate reproductive function as well as feeding behavior. The ependymocytes lining the ventricular wall of the hindbrain showed immunoreactivities to pancreatic glucokinase (GK), a key enzyme for glucose sensing in pancreatic B cells. Our goal in the present study was to test whether the GK-immunopositive ependymocytes in the wall of the fourth cerebroventricle (4V) play a role in regulating gonadal activity. Our approach was to determine the effect of injecting alloxan, a GK inhibitor, into the 4V on pulsatile luteinizing hormone (LH) secretion. Estrogen-primed ovariectomized rats received an injection of alloxan (10 or 20 μg/animal) into the 4V and blood samples were collected every 6 min for 3 h for measurement of blood LH, corticosterone and glucose levels. Pulsatile LH secretion was suppressed after alloxan injection and all pulse parameters were significantly (P<0.05) inhibited by 20 μg alloxan. Plasma corticosterone levels were increased significantly (P<0.05) by 20 μg alloxan, suggesting that LH pulse suppression by alloxan may be at least partly mediated by activation of the hypothalamo-pituitary-adrenal axis. The present results suggest that acute suppression of GK activity in the hindbrain inhibits pulsatile LH secretion in female rats, and supports the idea that GK-immunopositive ependymocytes may sense glucose levels in the cerebrospinal fluid and play a role in regulation of LH secretion.<br>
収録刊行物
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- Journal of Reproduction and Development
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Journal of Reproduction and Development 50 (3), 279-285, 2004
公益社団法人 日本繁殖生物学会
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詳細情報
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- CRID
- 1390001206335606144
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- NII論文ID
- 10027322370
- 220000094038
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- NII書誌ID
- AA10936678
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- ISSN
- 13484400
- 09168818
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- NDL書誌ID
- 6973226
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- PubMed
- 15226592
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
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- 抄録ライセンスフラグ
- 使用不可