Age-related changes in growth hormone-immunoreactive cells in the anterior pituitary gland of Jcl: Wistar-TgN (ARGHGEN) 1Nts rats (Mini rats)
Bibliographic Information
- Other Title
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- Age‐related changes in growth hormone‐immunoreactive cells in the anterior pituitary gland of Jcl: Wistar‐TgN (ARGHGEN) 1Nts rats (Mini rats)
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Abstract
ABSTRACT Rats of the Jcl: Wistar-TgN (ARGHGEN) 1Nts strain (Mini rats) are transgenic animals carrying an antisense RNA transgene for rat growth hormone (GH); they show poor somatic growth and a low blood GH level compared to age-matched wild-type Wistar (non-Mini) rats. The purpose of the present study was to investigate age-related changes in growth hormone-immunoreactive (GH-IR) cells in the anterior pituitary gland (AP) of Mini rats at four, six, and eight weeks of age. The body weight and size of the GH-IR cells of Mini rats was significantly lower than that of non-Mini rats at six and eight weeks of age; however, this difference was not observed at four weeks of age. The AP volume and the number of GH-IR cells in Mini rats were significantly smaller than those of the age-matched non-Mini rats at the three ages. These results suggest that the abnormal development of GH-IR cells in the AP induced by the GH antisense RNA transgene is responsible for the poor somatic growth and the low blood GH levels in Mini rats.
Journal
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- official journal of Congeital Anomalies Research Association of Japan
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official journal of Congeital Anomalies Research Association of Japan 46 (4), 188-193, 2006
The Japanese Teratology Society
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Details 詳細情報について
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- CRID
- 1390570465069200384
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- NII Article ID
- 10027385949
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- NII Book ID
- AN10066760
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- ISSN
- 24331503
- 17414520
- 00372285
- 09143505
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed