Association of tenascin-W expression with mineralization in mouse calvarial development
Bibliographic Information
- Other Title
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- Association of <i>tenascin‐W</i> expression with mineralization in mouse calvarial development
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Abstract
ABSTRACT Tenascin-W is a tenascin family member that forms part of a complex extracellular matrix, and previous studies have suggested its association with osteogenesis. In the present study we investigated the roles of tenascin-W in osteogenesis. We found that tenascin-W is expressed in osteoblasts at the edge of the developing bone domain prior to mineralization in mouse fetuses. Expression of tenascin-W was induced during the course of mineralization of the Kusa-A1 osteoblast cell line. In the interfrontal suture of postnatal mice, the anterior portion remains patent and the posterior portion closes by 4 weeks of age. Tenascin-W expression was downregulated at 1 week of age in the posterior frontal suture, whereas in the anterior suture, expression was maintained until the mice reached 4 weeks of age. Fibroblast growth factor 2 (FGF2)-bead application to the mouse fetal skull by ex-utero surgery accelerated osteoblast differentiation, but inhibited mineralization with a downregulation of tenascin-W expression. These results suggest that tenascin-W is involved in osteoblast maturation (i.e. mineralization).
Journal
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- official journal of Congeital Anomalies Research Association of Japan
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official journal of Congeital Anomalies Research Association of Japan 49 (2), 77-84, 2009
The Japanese Teratology Society
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Details 詳細情報について
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- CRID
- 1390851961199555200
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- NII Article ID
- 10027388147
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- NII Book ID
- AN10066760
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- ISSN
- 24331503
- 17414520
- 00372285
- 09143505
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed