Role of interleukin‐15 in the development of mouse olfactory nerve

• Tsuyoshi Umehara

• Jun Udagawa

• Kaoru Takamura

• Mitsuhiro Kimura

• Ryotaro Ishimitsu

• Hiroshi Kiyono

• Hideyuki Kawauchi

• Hiroki Otani

書誌事項

タイトル別名

• Role of interleukin-15 in the development of mouse olfactory nerve

抄録

ABSTRACT Interleukin (IL)-15 interacts with components of the IL-2 receptor (R) and exhibits T cell-stimulating activity similar to that of IL-2. In addition, IL-15 is widely expressed in many cell types and tissues, including the central nervous system. We provide evidence of a novel role of IL-15 in olfactory neurogenesis. Both IL-15 and IL-15Rα were expressed in neuronal precursor cells of the developing olfactory epithelium in mice. Adult IL-15Rα knockout mice had fewer mature olfactory neurons and proliferating cells than wild-type. Our results suggest that IL-15 plays an important role in regulating cell proliferation in olfactory neurogenesis.

収録刊行物

• 日本先天異常学会会報

  日本先天異常学会会報 49 (4), 253-257, 2009

  日本先天異常学会

キーワード

• Developmental Biology
• Embryology
• General Medicine
• Pediatrics, Perinatology and Child Health

詳細情報

• CRID: 1390289011245543296
• NII論文ID: 10027388257
• NII書誌ID: AN10066760
• DOI: 10.24540/cgafa.49.4_253
• DOI: 10.1111/j.1741-4520.2009.00246.x
• ISSN: 24331503
• ISSN: 17414520
• ISSN: 00372285
• ISSN: 09143505
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1741-4520.2009.00246.x
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1741-4520.2009.00246.x
• Web Site: https://search.jamas.or.jp/link/ui/2010166527
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
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