Immunohistochemical Observation of Notch Signaling in a Case of Calcifying Cystic Odontogenic Tumor

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  • Nakano Keisuke
    Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine
  • Chong Huat Siar
    Department of Oral Pathology, Oral Medicine & Periodontology, Faculty of Dentistry, University of Malaya
  • Tomida Mihoko
    Department of Oral Physiology, Matsumoto Dental University School of Dentistry
  • Matsuura Sachiko
    Department of Biology, Matsumoto Dental University School of Dentistry
  • Tsujigiwa Hidetsugu
    Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Nagatsuka Hitoshi
    Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Kawakami Toshiyuki
    Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine

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Abstract

Odontogenesis is a complex biological process both with epithelial and mesenchymal tissues, and this process directly reflects the development of odontogenic neoplasms. Therefore, we have examined Notch signaling in a case of calcifying cystic odontogenic tumor, with ameloblastic fibroma and odontogenic myxoma cases as controls. In these specimens, Notch-positive-products were present both in the epithelial and ectomesenchymal components in the calcifying cystic odontogenic tumor and the ameloblastic fibroma case, but negative in the odontogenic myxoma case, having no odontogenic epithelial islands to IHC and ISH examinations. Therefore, the examination results suggest that Notch signaling plays some important roles in cytological differentiation or acquisition of tissue-specific characteristics between odontogenic epithelium and odontogenic ectomesenchymal tissues.

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