Association Between Circulating Monocyte Subsets and In-Stent Restenosis After Coronary Stent Implantation in Patients With ST-Elevation Myocardial Infarction

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Author(s)

    • LIU Yong
    • Department of Cardiovascular Medicine, Wakayama Medical University
    • OZAKI Yuichi
    • Department of Cardiovascular Medicine, Wakayama Medical University
    • KUROI Akio
    • Department of Cardiovascular Medicine, Wakayama Medical University
    • OKOCHI Keishi
    • Department of Cardiovascular Medicine, Wakayama Medical University
    • INO Yasushi
    • Department of Cardiovascular Medicine, Wakayama Medical University

Abstract

<b><i>Background:</i></b> Recent studies have shown that monocytes in human peripheral blood are heterogeneous. The clinical significance of 2 distinct monocyte subsets as a marker of late in-stent restenosis (ISR) following implantation of bare-metal stents (BMSs) in patients with acute myocardial infarction (AMI) was examined. <b><i>Methods and Results:</i></b> Seventy-one consecutive patients with AMI who underwent BMS implantation were enrolled in the study. Peripheral blood was collected 12 days after AMI onset. Two distinct monocyte subsets (CD14<sup>+</sup>CD16<sup>-</sup>CCR2<sup>+</sup> and CD14<sup>+</sup>CD16<sup>+</sup>CX3CR1<sup>+</sup>) were measured by flow cytometry. All patients underwent angiography at a scheduled follow up after 9 months. CD14<sup>+</sup>CD16<sup>+</sup>CX3CR1<sup>+</sup> monocyte subset counts were significantly higher in patients with restenosis than in patients without restenosis, whereas neither the total monocytes nor the CD14<sup>+</sup>CD16<sup>-</sup>CCR2<sup>+</sup> subset counts differed significantly between the 2 groups of patients. There was also a significant positive correlation between the CD14<sup>+</sup>CD16<sup>+</sup>CX3CR1<sup>+</sup> monocyte counts and angiographic late lumen loss. In multivariate analysis, the CD14<sup>+</sup>CD16<sup>+</sup>CX3CR1<sup>+</sup> monocyte count was an independent predictor for in-stent late lumen loss. <b><i>Conclusions:</i></b> CD14<sup>+</sup>CD16<sup>+</sup>CX3CR1<sup>+</sup> monocytes might have a role in ISR following coronary BMS implantation in patients with AMI. (<i>Circ J</i> 2010; <b>74:</b> 2585-2591)<br>

Journal

  • Circulation Journal

    Circulation Journal 74(12), 2585-2591, 2010-11-25

    The Japanese Circulation Society

References:  27

Cited by:  4

Codes

  • NII Article ID (NAID)
    10027424225
  • NII NACSIS-CAT ID (NCID)
    AA11591968
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13469843
  • Data Source
    CJP  CJPref  J-STAGE 
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