Prevalence and Clinical Implication of Metabolic Syndrome in Chronic Heart Failure : Report From MetS-CHF Study

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Author(s)

    • MIURA Yutaka
    • Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
    • FUKUMOTO Yoshihiro
    • Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
    • SHIBA Nobuyuki
    • Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
    • MIURA Toshiro
    • Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine
    • SHIMADA Kazunori
    • Department of Cardiovascular Medicine, Juntendo University School of Medicine
    • IWAMA Yoshitaka
    • Department of Cardiovascular Medicine, Juntendo University School of Medicine
    • TAKAGI Atsutoshi
    • Department of Cardiovascular Medicine, Juntendo University School of Medicine
    • YAMADA Akira
    • Division of Cardiovascular Medicine, Aso-Iizuka Hospital
    • KINUGAWA Shintaro
    • Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
    • ASAKURA Masanori
    • Cardiovascular Division of Internal Medicine, National Cerebral and Cardiovascular Center
    • TSUTSUI Hiroyuki
    • Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
    • DAIDA Hiroyuki
    • Department of Cardiovascular Medicine, Juntendo University School of Medicine
    • MATSUZAKI Masunori
    • Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine
    • TOMOIKE Hitonobu
    • Cardiovascular Division of Internal Medicine, National Cerebral and Cardiovascular Center
    • SHIMOKAWA Hiroaki
    • Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine

Abstract

<b><i>Background:</i></b> Metabolic syndrome (MetS) is a pathological condition with a clustering of metabolic components and is a well-known risk and prognostic factor for ischemic heart disease (IHD). However, the prevalence and clinical significance of MetS remain to be fully elucidated in chronic heart failure (CHF), an important clinical syndrome caused by various cardiac abnormalities. <b><i>Methods and Results:</i></b> The present nationwide, large-scale clinical study enrolled 3,603 patients with stage C/D CHF from 6 institutes in Japan. First, the prevalence of MetS in CHF patients was demonstrated to be 45% in males and 19% in females, which is more than double compared with the general population in Japan. The CHF patients with MetS were characterized by younger age, higher prevalence of current smoking and drinking, IHD, and hypertensive heart disease, whereas the prevalence of HF with preserved ejection fraction and MetS was higher in elderly female patients. Next, the contribution of the metabolic components (waist circumference, hypertension, glucose intolerance/diabetes mellitus and dyslipidemia) was found to be comparable between the ischemic and the non-ischemic CHF patients. <b><i>Conclusions:</i></b> The prevalence of MetS in CHF patients is more than double compared with the general population in Japan and suggest that the metabolic components may have a substantial effect on the development of both ischemic and non-ischemic CHF. (<i>Circ J</i> 2010; <b>74:</b> 2612-2621)<br>

Journal

  • Circulation Journal

    Circulation Journal 74(12), 2612-2621, 2010-11-25

    The Japanese Circulation Society

References:  39

Cited by:  10

Codes

  • NII Article ID (NAID)
    10027424317
  • NII NACSIS-CAT ID (NCID)
    AA11591968
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13469843
  • Data Source
    CJP  CJPref  J-STAGE 
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