Tissue Characterization of Coronary Plaques and Assessment of Thickness of Fibrous Cap Using Integrated Backscatter Intravascular Ultrasound : Comparison With Histology and Optical Coherence Tomography

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Author(s)

    • KAWASAKI Masanori
    • Regeneration & Advanced Medical Science, Gifu University Graduate School of Medicine
    • HATTORI Arihiro
    • Regeneration & Advanced Medical Science, Gifu University Graduate School of Medicine
    • ISHIHARA Yoshiyuki
    • Regeneration & Advanced Medical Science, Gifu University Graduate School of Medicine
    • OKUBO Munenori
    • Regeneration & Advanced Medical Science, Gifu University Graduate School of Medicine
    • NISHIGAKI Kazuhiko
    • Regeneration & Advanced Medical Science, Gifu University Graduate School of Medicine
    • TAKEMURA Genzou
    • Regeneration & Advanced Medical Science, Gifu University Graduate School of Medicine
    • SAIO Masanao
    • Department of Immunopathology, Gifu University Graduate School of Medicine
    • TAKAMI Tsuyoshi
    • Department of Immunopathology, Gifu University Graduate School of Medicine
    • MINATOGUCHI Shinya
    • Regeneration & Advanced Medical Science, Gifu University Graduate School of Medicine

Abstract

<b><i>Background:</i></b> The purpose of this study was to develop a new online integrated backscatter intravascular ultrasound (IB-IVUS) system and to validate its ability to measure fibrous cap thickness by comparing IB-IVUS images with those from optical coherence tomography (OCT). <b><i>Methods and Results:</i></b> Images were acquired from 125 segments of 26 coronary arteries obtained at autopsy from 11 cadavers. In the training study (n=30), 242 regions-of-interest on color-coded maps were compared with histology. In the validation study, 95 cross-sections were diagnosed by IB-IVUS and histology. In 24 patients with stable angina, 28 arterial cross-sections were imaged by IB-IVUS and OCT in vivo. In the training study, cutoff values of 39 decibels (dB) and 17dB were the optimal predictors of lipid pool/fibrosis and fibrosis/calcification, respectively, with 38-MHz mode; 42dB and 20dB, respectively, with 43-MHz mode. In the validation study, IB classified the fibrous, lipid-rich and fibrocalcific components with an accuracy of 92%, 91% and 95%, respectively. Agreement between the histological and IB-IVUS diagnoses was excellent (Cohen's κ=0.83). There was a correlation between the fibrous cap thickness measured by IB-IVUS and OCT (r=0.74, P<0.001). <b><i>Conclusions:</i></b> The IB-IVUS system with improved resolution provides high diagnostic accuracy for the analysis of the tissue characteristics of coronary plaques, and enables estimation of the thickness of the fibrous cap in the clinical setting. (<i>Circ J</i> 2010; <b>74:</b> 2641-2648)<br>

Journal

  • Circulation Journal

    Circulation Journal 74(12), 2641-2648, 2010-11-25

    The Japanese Circulation Society

References:  28

Cited by:  8

Codes

  • NII Article ID (NAID)
    10027424454
  • NII NACSIS-CAT ID (NCID)
    AA11591968
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13469843
  • Data Source
    CJP  CJPref  J-STAGE 
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