Prediction of Chronic Renal Insufficiency After Coronary Angiography by an Early Increase in Oxidative Stress and Decrease in Glomerular Filtration Rate

• Tajiri Kazuko

  Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba

• Maruyama Hidekazu

  Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba

• Sato Akira

  Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba

• Shimojo Nobutake

  Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba

• Saito Takumi

  Department of Internal Medicine, Moriya General Daiichi Hospital

• Endo Masae

  Department of Internal Medicine, Moriya General Daiichi Hospital

• Aihara Hideaki

  Department of Internal Medicine, Moriya General Daiichi Hospital

• Kawano Satoru

  Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba

• Watanabe Shigeyuki

  Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba

• Sakai Satoshi

  Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba

• Aonuma Kazutaka

  Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba

抄録

Background: Oxidative stress caused by contrast medium is thought to be one of the main mechanisms of contrast-induced acute kidney injury. A prospective study was conducted to evaluate the relationship between oxidative stress caused by contrast agent administration and long-term renal function. Methods and Results: Thirty-six consecutive patients who underwent coronary angiography were enrolled. Urinary F2-isoprostane, a marker of oxidative stress, was measured at baseline and 24h after angiography, and serum creatinine was measured at baseline, 24h and 1 year after the procedure. The change in estimated glomerular filtration rate (eGFR) at 1 year after angiography correlated significantly with the change in eGFR at 24h after angiography (r=0.729, P<0.001). We also found a significant correlation between the increase in urinary F2-isoprostane at 24h and the decrease in eGFR at 1 year (r=0.439, P=0.022). In multivariate analysis, the decrease in eGFR at 1 year after coronary angiography correlated with the increase in F2-isoprostane at 24h after angiography as well as the decrease in eGFR at 24h after angiography (P=0.039 and P<0.001, respectively). Conclusions: Contrast-induced nephrotoxicity might be transient; however, an early decrease in eGFR and increase in oxidative stress are associated with chronic renal insufficiency. Careful long-term follow-up and adequate medical intervention are necessary for these patients. (Circ J 2011; 75: 437-442)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 75 (2), 437-442, 2011

  一般社団法人 日本循環器学会

キーワード

• Contrast-induced nephropathy
• Contrast medium
• Coronary angiography
• Oxidative stress

詳細情報

• CRID: 1390282680080883584
• NII論文ID: 10027427336
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-10-0622
• COI: 1:STN:280:DC%2BC3M7ks1Oksg%3D%3D
• ISSN: 13474820
• ISSN: 13469843
• PubMed: 21099127
• Web Site: https://www.jstage.jst.go.jp/article/circj/75/2/75_CJ-10-0622/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2011192619
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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