Integrated examination about the effect of the postnatal environment on the central nervous system

• Yoshihara Toshihiro

  Pediatric dentistry, Hokkaido University Hospital

Bibliographic Information

Other Title

• 生後の環境が中枢神経系に与える影響についての統合的理解

Abstract

In our recent studies, the effect of maternal deprivation (MD) in the early postnatal period on the function of the hypothalamus-pituitary-adrenocortical (HPA) axis in adulthood. The following results were obtained.<BR>(1) MD in the postnatal period induces long-term effects on stress responsibility of the HPA axis. Furthermore, a critical age of the pup at the time of MD exists as well as a critical length of MD for inducing these effects.<BR>(2) It was suggested that the long-term effects of MD on the HPA axis might be mediated by decreasing negative feedback regulation in the hippocampus of the HPA axis.<BR>(3) Methamphetamine-induced extension of the period of the clock gene Per I expression was more enhanced in the mice subjected to MD in the early postnatal period than control.

Journal

• The Japanese Journal of Pediatric Dentistry

  The Japanese Journal of Pediatric Dentistry 46 (5), 497-500, 2008

  The Japanese Society of Pediatric Dentistry

Keywords

• Maternal deprivation
• Hypothalamus-pituitary-adrenocortical axis
• Negative feedback regulation
• Clock gene

Details

• CRID: 1390001204686616832
• NII Article ID: 10027487044
• NII Book ID: AN00116228
• DOI: 10.11411/jspd1963.46.5_497
• ISSN: 05831199
• Web Site: https://search.jamas.or.jp/link/ui/2009124615
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed