Acid Labile ComX Pheromone from<i>Bacillus mojavensis</i>RO-H-1

• OKADA Masahiro

  Graduate School of Bioagricultural Sciences, Nagoya University

• YAMAGUCHI Hisao

  Graduate School of Bioagricultural Sciences, Nagoya University

• SATO Isao

  Graduate School of Bioagricultural Sciences, Nagoya University

• TSUJI Fumitada

  Graduate School of Bioagricultural Sciences, Nagoya University

• QI Jianhua

  Graduate School of Bioagricultural Sciences, Nagoya University

• DUBNAU David

  Public Health Research Institute

• SAKAGAMI Youji

  Graduate School of Bioagricultural Sciences, Nagoya University

書誌事項

タイトル別名

• Acid Labile ComX Pheromone from Bacillus mojavensis RO-H-1

抄録

Bacillus mojavensis strain RO-H-1 produces a posttranslationally modified hexapeptide, the ComX_RO-H-1 pheromone, that stimulates natural genetic competence controlled by quorum sensing. LC/ESI-MS analysis of partially purification of the ComX_RO-H-1 pheromone suggested a precise modification in its tryptophan residue. The corresponding ComX_RO-H-1 pheromone prepared by solid-phase synthesis was identical to the natural pheromone, and showed significant biological activity. These results indicated that the posttranslational modification of the ComX_RO-H-1 pheromone was geranylation on the tryptophan residue, resulting in the formation of a tricyclic structure. The ComX_RO-H-1 pheromone was immediately dehydrated by acid because of its extreme acid lability.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 71 (7), 1807-1810, 2007

  公益社団法人 日本農芸化学会

キーワード

• <I>Bacillus mojavensis</I>
• ComX
• posttranslational modification
• quorum sensing
• tryptophan

詳細情報

• CRID: 1390282681457225600
• NII論文ID: 10027517089
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.70245
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 8840323
• Web Site: http://id.ndl.go.jp/bib/8840323
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8840323
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.70245
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可