Studies on the Later Stage of the Biosynthesis of Pleuromutilin

• TSUKAGOSHI Tae

  Division of Chemistry, Graduate School of Science, Hokkaido University

• TOKIWANO Tetsuo

  Division of Chemistry, Graduate School of Science, Hokkaido University

• OIKAWA Hideaki

  Division of Chemistry, Graduate School of Science, Hokkaido University

抄録

Mutilin (4) and deoxy analogues 2 and 3 are biosynthetic precursors of pleuromutilin (1) in the later stage of biosynthesis. Precursors 2 and 3 are required for studies on the oxygenation steps in biosynthesis, and were synthesized from readily available 1 via 4 by deoxygenation of the hydroxy groups. Feeding experiments with the ²H-labeled precursors confirmed their microbial conversion into 1.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 71 (12), 3116-3121, 2007

  公益社団法人 日本農芸化学会

キーワード

• pleuromutilin
• diterpene biosynthesis
• synthesis of <SUP>2</SUP>H-labeled precursor
• microbial conversion

詳細情報

• CRID: 1390282681454697472
• NII論文ID: 10027522565
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.70547
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 9327356
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9327356
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.70547
• 本文言語コード: en
• データソース種別:
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• 抄録ライセンスフラグ: 使用不可