Antidepressant-Like Effect of Onion (<i>Allium cepa</i>L.) Powder in a Rat Behavioral Model of Depression

DOI Web Site Web Site 被引用文献14件 参考文献29件
  • SAKAKIBARA Hiroyuki
    Departments of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate School Institute for Environmental Sciences, University of Shizuoka
  • YOSHINO Saki
    Departments of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate School
  • KAWAI Yoshichika
    Departments of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate School
  • TERAO Junji
    Departments of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate School

書誌事項

タイトル別名
  • Antidepressant-Like Effect of Onion (Allium cepa L.) Powder in a Rat Behavioral Model of Depression

この論文をさがす

抄録

The present study evaluated the antidepressant-like effect of the quercetin-rich vegetable, onion, by using the rat behavioral model of depression, the forced swimming test (FST). Daily administration of onion powder at a dosage of 50 mg/kg of body weight/day for 14 days significantly reduced the immobility time in FST without changing the motor dysfunction, indicating that the daily consumption of onion exerted antidepressant-like activity. The plasma corticosterone level was elevated after an FST trial, and pretreatment with onion powder did not modulate this elevation. Although the FST trial tended to increase the dopaminergic activity in the rat hypothalamus, the administration of onion powder (50 mg/kg) suppressed the increase in the turnover of this neurotransmitter. However, the same prevention was also observed with a higher dosage of onion, in which no significant antidepressant effect was apparent. The results of the present study suggest that onion exerted antidepressant-like activity in a behavioral model that acted independently of the hypothalamic-pituitary-adrenal axis.

収録刊行物

被引用文献 (14)*注記

もっと見る

参考文献 (29)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ