Chebulagic Acid Is a Potent .ALPHA.-Glucosidase Inhibitor

• GAO Hong

  Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University

• HUANG Yi-Na

  Department of Public Health, Hua Xi Medical Center of Sichuan University

• GAO Bo

  Department of Public Health, Hua Xi Medical Center of Sichuan University

• KAWABATA Jun

  Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University

Bibliographic Information

Other Title

• Chebulagic acid is a potent α-glucosidase inhibitor
• Chebulagic acid is a potent a glucosidase inhibitor

Abstract

Chebulagic acid, isolated form Terminalia chebula Retz, proved to be a reversible and non-competitive inhibitor of maltase with a K_i value of 6.6 μM. The inhibitory influence of chebulagic acid on the maltase-glucoamylase complex was more potent than on the sucrase-isomaltase complex. The magnitude of α-glucosidase inhibition by chebulagic acid was greatly affected by its origin. These results show a use for chebulagic acid in managing type-2 diabetes.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 72 (2), 601-603, 2008

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• α-glucosidase
• maltase inhibitor
• <I>Terminalia chebula</I> Retz
• chebulagic acid

Details

• CRID: 1390282681456617984
• NII Article ID: 10027524884
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.70591
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 9410468
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9410468
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.70591
• Web Site: https://search.jamas.or.jp/link/ui/2008216589
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed