Chlorogenic Acid and Its Metabolite<i>m</i>-Coumaric Acid Evoke Neurite Outgrowth in Hippocampal Neuronal Cells

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  • ITO Hideyuki
    Department of Pharmacognosy, Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • SUN Xiu-Lan
    Department of Pharmacognosy, Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • WATANABE Makiko
    Department of Medical Technology, Graduate School of Health Sciences, Okayama University
  • OKAMOTO Motoi
    Department of Medical Technology, Graduate School of Health Sciences, Okayama University
  • HATANO Tsutomu
    Department of Pharmacognosy, Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

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  • Chlorogenic Acid and Its Metabolite m-Coumaric Acid Evoke Neurite Outgrowth in Hippocampal Neuronal Cells

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We evaluated the neurotrophic activity of dietary polyphenols by using primary cultures of fetal rat hippocampal neurons in a serum-free medium. Among the tested compounds, chlorogenic acid and its metabolite, m-coumaric acid, together with catechins and flavanone, were found to promote neuronal differentiation comparable to the phytochemical, honokiol, which has been reported to show potent neurotrophic activity. The present findings may contribute to the development of further neurotrophic studies on dietary polyphenols and their metabolites.

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