Ingested β-carotene enhances glutathione level and up-regulates the activity of cysteine cathepsin in murine splenocytes

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  • TAKEDA Saki
    Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushima
  • BANDO Noriko
    Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushima
  • YAMANISHI Rintaro
    Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushima

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タイトル別名
  • Ingested .BETA.-Carotene Enhances Glutathione Level and up-Regulates the Activity of Cysteine Cathepsin in Murine Splenocytes
  • Ingested v carotene enhances glutathione level and up regulates the activity of cysteine cathepsin in murine splenocytes

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To elucidate health benefits of β-carotene, especially on immunity, we measured redox-related indices in spleen cells from BALB/c mice supplemented with various amounts of β-carotene. In mice supplemented with β-carotene in their diet, glutathione, an intracellular anti-oxidation agent, increased in their splenocytes. This change was highly correlated with the accumulation of β-carotene, but not with that of retinol. The increase in glutathione was accompanied by an increase in mRNA for γ-glutamylcysteine synthetase, a rate-limiting enzyme for glutathione synthesis. The higher the glutathione content was in the spleen cells, the higher the activity of cysteine cathepsin became in crude antigen-presenting cells contained in the spleen. These data suggest that accumulated β-carotene in splenocytes, without being metabolized, caused an increase in the intracellular glutathione level, thereby anti-oxidatively supporting the activity of redox-sensitive lysosomal protease, which is involved in antigen-presentation.

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