Effect of Dietary Soybean Protein Level on the Plasma Homocysteine Concentration in Rats

  • OKAWA Hiroshi
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
  • MORITA Tatsuya
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
  • SUGIYAMA Kimio
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University

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Abstract

There was an inverse correlation between the plasma homocysteine concentration and dietary protein level or protein intake when a soybean protein isolate (SPI) was used as a protein source for rats. The hepatic cystathionine β-synthase activity increased in response to the dietary SPI level. The results suggest that a high-protein diet might be an effective means to lower the plasma homocysteine concentration, probably through enhancement of the homocysteine-metabolizing activity.

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