Hyperhomocysteinemia Induced by Guanidinoacetic Acid Is Effectively Suppressed by Choline and Betaine in Rats

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  • SETOUE Minoru
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
  • OHUCHI Seiya
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
  • MORITA Tatsuya
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
  • SUGIYAMA Kimio
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University

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Abstract

Rats were fed 25% casein (25C) diets differing in choline levels (0–0.5%) with and without 0.5% guanidinoacetic acid (GAA) or 0.75% L-methionine for 7 d to determine the effects of dietary choline level on experimental hyperhomocysteinemia. The effects of dietary choline (0.30%) and betaine (0.34%) on GAA- and methionine-induced hyperhomocysteinemia were also compared. Dietary choline suppressed hyperhomocysteinemia induced by GAA, but not by methionine, in a dose-dependent manner. GAA-induced enhancement of the plasma homocysteine concentration was suppressed by choline and betaine to the same degree, but the effects of these compounds were relatively small on methionine-induced hyperhomocysteinemia. Dietary supplementation with choline and betaine significantly increased the hepatic betaine concentration in rats fed a GAA diet, but not in rats fed a methionine diet. These results indicate that choline and betaine are effective at relatively low levels in reducing plasma homocysteine, especially under the condition of betaine deficiency without a loading of homocysteine precursor.

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