Manipulation of Major Membrane Lipid Synthesis and Its Effects on Sporulation in<i>Saccharomyces cerevisiae</i>

• DENG Lan

  Department of Biotechnology, The University of Tokyo

• NAGASAWA Jumpei

  Department of Biotechnology, The University of Tokyo

• ONO Yusuke

  Department of Biotechnology, The University of Tokyo

• ISHIKAWA Yasuhisa

  Department of Biotechnology, The University of Tokyo

• KAKIHARA Toru

  Department of Biotechnology, The University of Tokyo

• FUKUDA Ryouichi

  Department of Biotechnology, The University of Tokyo

• OHTA Akinori

  Department of Biotechnology, The University of Tokyo

書誌事項

タイトル別名

• Manipulation of Major Membrane Lipid Synthesis and Its Effects on Sporulation in Saccharomyces cerevisiae

抄録

During the sporulation process of Saccharomyces cerevisiae, meiotic progression is accompanied by de novo formation of the prospore membrane inside the cell. However, it remains to be determined whether certain species of lipids are required for spore formation in yeast. In this study, we analyzed the requirement of the synthesis of phosphatidylethanolamine (PE), phosphatidylcholine (PC), and ergosterol for spore formation using strains in which the synthesis of these lipids can be controlled. When synthesis of PE and PC was repressed, sporulation efficiency decreased. This suggests that synthesis of these phospholipids is vital to proper sporulation. In addition, sporulation was also impaired in cells with a lowered sterol content, raising the possibility that sterol content is also important for spore formation.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 72 (9), 2362-2368, 2008

  公益社団法人 日本農芸化学会

キーワード

• <I>Saccharomyces cerevisiae</I>
• sporulation
• phosphatidylethanolamine
• phosphatidylcholine
• sterol

詳細情報

• CRID: 1390282681456007424
• NII論文ID: 10027532009
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.80265
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 9749265
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9749265
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.80265
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可