Synthesis and Anti-Angiogenic Activity of Cortistatin Analogs

• SATO Yuuki

  Graduate School of Agricultural Science, Tohoku University

• KAMIYAMA Hiroshi

  Graduate School of Science and Engineering, Saitama University Chemical Library and Bioprobe Research Group, RIKEN Advanced Science Institute

• USUI Takeo

  Chemical Library and Bioprobe Research Group, RIKEN Advanced Science Institute Graduate School of Life and Environmental Sciences, University of Tsukuba

• SAITO Tamio

  Chemical Library and Bioprobe Research Group, RIKEN Advanced Science Institute

• OSADA Hiroyuki

  Graduate School of Science and Engineering, Saitama University Chemical Library and Bioprobe Research Group, RIKEN Advanced Science Institute

• KUWAHARA Shigefumi

  Graduate School of Agricultural Science, Tohoku University

• KIYOTA Hiromasa

  Graduate School of Agricultural Science, Tohoku University

Abstract

Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of HUVEC.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 72 (11), 2992-2997, 2008

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• <I>Cortisium simplex</I>
• cortistatin A
• synthesis
• HUVEC
• angiogenesis

Details

• CRID: 1390282681455950080
• NII Article ID: 10027534251
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.80562
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 9724037
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9724037
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.80562
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed