Identification of Ecl Family Genes That Extend Chronological Lifespan in Fission Yeast

• OHTSUKA Hokuto

  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

• OGAWA Yuki

  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

• MIZUNO Hiroyuki

  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

• MITA Satoka

  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

• AIBA Hirofumi

  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

Abstract

In fission yeast, we identified two genes, named ecl2⁺ and ecl3⁺, that are paralogous to ecl1⁺, which extends the chronological lifespan. Both ecl2⁺ and ecl3⁺ extend the chronological lifespan when overexpressed as ecl1⁺. ecl2⁺ and ecl3⁺ encode 84- and 89-amino acid polypeptides respectively that are not annotated in the current database. The Ecl2 protein is localized mainly in the nucleus, as Ecl1. These results suggest that ecl1⁺, ecl2⁺, and ecl3⁺ have overlapping functions in the regulation of chronological lifespan.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 73 (4), 885-889, 2009

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• chronological lifespan
• fission yeast
• aging

Details

• CRID: 1390001206480293376
• NII Article ID: 10027539873
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.80804
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 10213118
• Web Site: http://id.ndl.go.jp/bib/10213118
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10213118
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.80804
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed