Formation of Lysophosphatidic Acid, a Wound-Healing Lipid, during Digestion of Cabbage Leaves

Formation of Lysophosphatidic Acid, a Wound-Healing Lipid, during Digestion of Cabbage Leaves

- Tanaka Tamotsu TANAKA Tamotsu
- Department of Applied Biological Science, Fukuyama University
- Horiuchi Gou HORIUCHI Gou
- Department of Applied Biological Science, Fukuyama University
- Matsuoka Megumi [他] MATSUOKA Megumi
- Department of Applied Biological Science, Fukuyama University
- HIRANO Kaoru
- Department of Applied Biological Science, Fukuyama University
- TOKUMURA Akira
- Institute of Health Biosciences, University of Tokushima Graduate School
- KOIKE Tohru
- Department of Functional Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University
- SATOUCHI Kiyoshi
- Department of Applied Biological Science, Fukuyama University

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Author(s)

- Tanaka Tamotsu TANAKA Tamotsu
- Department of Applied Biological Science, Fukuyama University
- Horiuchi Gou HORIUCHI Gou
- Department of Applied Biological Science, Fukuyama University
- Matsuoka Megumi [他] MATSUOKA Megumi
- Department of Applied Biological Science, Fukuyama University
- HIRANO Kaoru
- Department of Applied Biological Science, Fukuyama University
- TOKUMURA Akira
- Institute of Health Biosciences, University of Tokushima Graduate School
- KOIKE Tohru
- Department of Functional Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University
- SATOUCHI Kiyoshi
- Department of Applied Biological Science, Fukuyama University

Abstract

Lysophosphatidic acid (LPA) is a lipid mediator that plays a role in the process of wound healing in animal tissues, including the digestive tract. We determined LPA in several foodstuffs, and found that cabbage leaves were the richest source of LPA. We also found that, at 22 and 195 nmol/g (wet weight), LPA and phosphatidic acid (PA) were respectively formed during mastication of raw cabbage leaves and that the resulting PA was converted to LPA by pancreatic phospholipase A<SUB>2</SUB>. The lipid extract obtained from ground cabbage leaves promoted the proliferation of Swiss 3T3 fibroblasts and the motility of HGC-27 cells, stomach-derived epithelial-like cells, at physiologically relevant concentrations. These activities of cabbage lipids were inhibited by Ki16425, an LPA-receptor antagonist. LPA formed during the digestion of cabbage leaves may be one of the components in the beneficial effect of ingested cabbage on a damaged digestive tract.

Journal

Bioscience, Biotechnology, and Biochemistry

Bioscience, Biotechnology, and Biochemistry 73(6), 1293-1300, 2009-06-23

Japan Society for Bioscience, Biotechnology, and Agrochemistry

References: 32

1

<no title>

YE X

Nature 435, 104-108, 2005

Cited by (1)
2

<no title>

STURM A

Gastroenterology 117, 368-377, 1999

Cited by (1)
3

<no title>

DENG W

Am. J. Physiol. Gastrointest. Liver Physiol. 284, G821-G829, 2003

Cited by (1)
4

<no title>

LI C

J. Exp. Med. 202, 975-986, 2005

Cited by (1)
5

<no title>

CHOI S

Am. J. Physiol. Gastrointest. Liver Physiol. 292, G98-G112, 2007

Cited by (1)
6

<no title>

TANAKA T

J. Lipid Res. 45, 2145-2150, 2004

Cited by (1)
7

<no title>

BLIGH EG

Can. J. Biochem. Physiol. 37, 911-917, 1959

Cited by (1)
8

<no title>

BARTLETT GR

J. Biol. Chem. 234, 466-468, 1959

Cited by (1)
9

<no title>

HANAHAN DJ

J. Biol. Chem. 172, 191-198, 1948

Cited by (1)
10

<no title>

TARNAWSKI A

Aliment. Pharmacol. Ther. 5, 79-90, 1991

Cited by (1)
11

<no title>

SHIDA D

Exp. Cell Res. 301, 168-178, 2004

Cited by (1)
12

<no title>

DAVIDSON FM

Biochem. J. 69, 458-466, 1958

Cited by (1)
13

<no title>

LONG C

Biochem. J. 102, 216-220, 1967

Cited by (1)
14

<no title>

OHTA H

Mol. Pharmacol. 64, 994-1005, 2003

Cited by (1)
15

<no title>

CHENEY G

Calif. Med. 70, 10-15, 1949

Cited by (1)
16

<no title>

MOOLENAAR W. H.

BioEssays 26, 870-881, 2004

DOI Cited by (5)
17

<no title>

TOKUMURA A.

J. Cell. Biochem. 92, 869-881, 2004

DOI Cited by (4)
18

Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding

KINGSBURY M. A.

Nat. Neurosci. 6, 1292-1299, 2003

Cited by (3)
19

<no title>

TANAKA M.

J. Biol. Chem. 281, 25822-25830, 2006

DOI Cited by (11)
20

<no title>

TOKUMURA A

J. Biol. Chem. 277, 39436-39442, 2002

DOI Cited by (21)
21

Serum lysophosphatidic acid is produced through diverse phospholipase pathways

AOKI J.

J Biol Chem. 277, 48737-48744, 2002

DOI Cited by (8)
22

Multiple mechanisms linked to platelet activation result in lysophosphatidic acid and sphingosine 1-phosphate generation in blood

SANO T.

J Biol Chem 277, 21197-21206, 2002

DOI Cited by (9)
23

<no title>

UMEZU-GOTO M.

J. Cell Biol. 158, 227-233, 2002

DOI Cited by (26)
24

<no title>

BALAZS L

Am. J. Physiol. Regul. Integr. Comp. Physiol. 280, R466-R472, 2001

Cited by (3)
25

Lysophosphatidic acid protects and rescues intestinal epithelial cells from radiation- and chemotherapy-induced apoptosis

DENG W.

Gastroenterology 123, 206-216, 2002

DOI Cited by (4)
26

<no title>

SUGIURA T

J. Lipid Res. 43, 2049-2055, 2002

Cited by (4)
27

<no title>

TOKUMURA A

Lipids 13, 468-472, 1978

Cited by (2)
28

<no title>

TANAKA T.

Lipids 31, 1173-1178, 1996

Cited by (2)
29

<no title>

TOJO H

Eur. J. Biochem. 215, 81-90, 1993

Cited by (1)
30

<no title>

HIROHARA J

Biochim. Biophys. Acta 919, 231-238, 1987

Cited by (1)
31

<no title>

HOGAN DL

Aliment. Pharmacol. Ther. 8, 475-488, 1994

Cited by (2)
32

GPR92 as a new G12/13 and Gq coupled lysophosphatidic acid receptor that increases cAMP : LPA5

LEE C. W.

J Biol Chem. 281, 23589-23597, 2006

DOI Cited by (9)

Cited by: 4

1

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田中保 , 盛重純一 , 喜田孝史 , 安藤千恵 , 木下正文 , 葛西彩香 , 大本真弓 , 瓜倉真衣 , 里内清 , 徳村彰

脂質生化学研究 52, 77-80, 2010-05-25

References (3)
2

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J-STAGE JASI References (39) Cited by (1)
3

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脂質生化学研究 55, 60-63, 2013-05-28

References (5)
4

Physiological role of lysophosphatidic acid and its relevance to diseases [in Japanese]

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生化學 83(6), 506-517, 2011-06-25

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Formation of Lysophosphatidic Acid, a Wound-Healing Lipid, during Digestion of Cabbage Leaves

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