Effects of Grape Seed Proanthocyanidin Extracts on Aortic Pulse Wave Velocity in Streptozocin Induced Diabetic Rats

• LI Xiao-li

  Department of Geriatrics, Qi-Lu Hospital of Shandong University Department of Drug Purchase and Supply, Qi-Lu Hospital of Shandong University

• LI Bao-ying

  Department of Geriatrics, Qi-Lu Hospital of Shandong University

• GAO Hai-qing

  Department of Geriatrics, Qi-Lu Hospital of Shandong University

• CHENG Mei

  Department of Geriatrics, Qi-Lu Hospital of Shandong University

• XU Ling

  Department of Geriatrics, Qi-Lu Hospital of Shandong University

• LI Xian-hua

  Department of Geriatrics, Qi-Lu Hospital of Shandong University

• MA Ya-bing

  Department of Geriatrics, Qi-Lu Hospital of Shandong University

抄録

Grape seed proanthocyanidin extracts (GSPEs) have been reported to be effective in treating arteriosclerosis, while little is known about therapeutic agents against diabetic macrovascular complications. We used streptozocin to induce diabetic rats. GSPEs (250 mg/kg of body weight) were administrated to diabetic rats for 24 weeks. Aortic blood pressure and pulse wave velocity (PWV) were determined in anesthetized rats. Serum glycated hemoglobin and advanced glycation end products (AGEs) were determined. An electronic microscope was used to observe the changes in aortic ultrastructure. Immunohistochemistry was used to evaluate the receptor of advanced glycation end product (RAGE) protein expression in aortic tissue. GSPEs significantly decreased aortic PWV, blood pressure, and aortic medial thickness (P<0.05), and inhibited the migration of vascular smooth muscle cells. GSPEs significantly reduced the AGEs (P<0.05) and the expression of RAGE in aortas of diabetic rats. GSPEs play an important role against diabetic macrovascular complications. This study may provide a new recognition of natural medicine for the treatment of diabetic macrovascular complications.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 73 (6), 1348-1354, 2009

  公益社団法人 日本農芸化学会

キーワード

• grape seed proanthocyanidin extracts
• diabetes mellitus
• macrovascular complications
• pulse wave velocity
• receptor of advanced glycation end products

詳細情報

• CRID: 1390001206480484224
• NII論文ID: 10027542401
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.90008
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 10267238
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10267238
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.90008
• Web Site: https://search.jamas.or.jp/link/ui/2010041062
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
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