Syntheses and Antimicrobial Activity of Tetrasubstituted Tetrahydrofuran Lignan Stereoisomers

• NAKATO Tomofumi

  Faculty of Agriculture, Ehime University

• YAMAUCHI Satoshi

  Faculty of Agriculture, Ehime University South Ehime Fisheries Research Center

• TAGO Ryosuke

  Faculty of Agriculture, Ehime University

• AKIYAMA Koichi

  Integrated Center for Sciences, Tarumi Station, Ehime University

• MARUYAMA Masafumi

  Faculty of Agriculture, Ehime University

• SUGAHARA Takuya

  Faculty of Agriculture, Ehime University South Ehime Fisheries Research Center

• KISHIDA Taro

  Faculty of Agriculture, Ehime University South Ehime Fisheries Research Center

• KOBA Yojiro

  Faculty of Agriculture, Ehime University

抄録

The syntheses of all stereoisomers of tetrasubstituted tetrahydrofuran lignan were accomplished, and the antimicrobial activity was examined. The 9,9′-diol compound bearing (7R,7′R,8R,8′R) and (7R,7′S,8R,8′R) stereochemistry showed the strongest antibacterial activity against Listeria denitrificans and Bacillus subtilis, respectively. It was also found that (−)-virgatusin bearing (7S,7′R,8S,8′S) stereochemistry had strongest antifungal activity.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 73 (7), 1608-1617, 2009

  公益社団法人 日本農芸化学会

キーワード

• lignan
• tetrahydrofuran lignan
• antimicrobial activity

詳細情報

• CRID: 1390282681455988608
• NII論文ID: 10027543720
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.90107
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 10303694
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10303694
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.90107
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可