Effect of Dietary Oils on Host Resistance to Fungal Infection in Psychologically Stressed Mice

• OARADA Motoko

  Medical Mycology Research Center, Chiba University

• IGARASHI Miki

  Biodynamic Chemistry, Graduate School of Life Science and Agriculture, Tohoku University

• TSUZUKI Tsuyoshi

  Food and Biomolecular Science, Graduate School of Life Science and Agriculture, Tohoku University

• KURITA Nobuyuki

  Medical Mycology Research Center, Chiba University

• GONOI Tohru

  Medical Mycology Research Center, Chiba University

• NIKAWA Takeshi

  Department of Nutrition, Tokushima University School of Medicine

• HIRASAKA Katsuya

  Department of Nutrition, Tokushima University School of Medicine

• MIYAZAWA Teruo

  Biodynamic Chemistry, Graduate School of Life Science and Agriculture, Tohoku University

• NAKAGAWA Kiyotaka

  Biodynamic Chemistry, Graduate School of Life Science and Agriculture, Tohoku University

• KAMEI Katsuhiko

  Medical Mycology Research Center, Chiba University

Abstract

Psychological stress can modulate host defense against invading pathogens. In this study, we investigated the effect of dietary oils on social isolation stress-induced modulation of host resistance to Paracoccidioides brasiliensis. In olive oil-fed mice, 3 weeks of isolation stress resulted in temporarily delayed clearance of this fungus in the liver compared with group-housed mice. By contrast, in soybean oil-fed mice, isolation stress had no significant effect on antifungal activity. The olive oil-fed mice showed greater liver interferon (IFN)-γ and interleukin (IL)-6 production in response to infection as compared with the soybean oil-fed mice. In the olive oil-fed mice, isolation stress led to greater infection-induced IFN-γ production in the liver compared with the group-housed animals. These results indicate that the modulatory effects of psychological stress on host resistance to P. brasiliensis can vary depending on dietary fatty acid composition.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 73 (9), 1994-1998, 2009

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• antifungal activity
• dietary olive oil
• dietary soybean oil
• interferon (IFN)-γ
• social isolation stress

Details

• CRID: 1390001206477854720
• NII Article ID: 10027545495
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.90184
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 10372404
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10372404
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.90184
• Web Site: https://search.jamas.or.jp/link/ui/2010058093
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed