Effects of Co-Administration of Tea Epigallocatechin-3-gallate (EGCG) and Caffeine on Absorption and Metabolism of EGCG in Humans

• NAKAGAWA Kiyotaka

  Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University

• NAKAYAMA Kayoko

  Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University

• NAKAMURA Miho

  Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University

• SOOKWONG Phumon

  Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University

• TSUDUKI Tsuyoshi

  Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University

• NIINO Hitoshi

  Central Research Institute, Ito En, Ltd.

• KIMURA Fumiko

  Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University

• MIYAZAWA Teruo

  Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University

Abstract

Based on the ratios of (−)-epigallocatechin-3-gallate (EGCG) and caffeine (CAF) levels found in commercial tea drinks, EGCG and CAF were co-administered to human volunteers at various EGCG/CAF ratios, and plasma EGCG was determined by high performance liquid chromatography with chemiluminescence detection. As for the results, in plasma taken after ingestion of a beverage containing 95 mg of EGCG alone, the area under the plasma EGCG concentration-time curve (AUC) was 857 ng·h/ml. A higher AUC (1,370 ng·h/ml) was observed when subjects ingested a beverage containing EGCG (95 mg) and a low amount of CAF (40 mg). In the case of ingestion of a beverage containing EGCG (95 mg) and a high amount of CAF (180 mg), the AUC tended to be somewhat higher (1,165 ng·h/ml), but not significantly so, compared with the beverage with EGCG alone. These findings (modulation of plasma EGCG level by CAF) provide ideas for modulating the bioavailability of tea catechins, which can be applied to tea-related drinks and foods.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 73 (9), 2014-2017, 2009

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• tea catechins
• caffeine
• human plasma

Details

• CRID: 1390001206477857920
• NII Article ID: 10027545591
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.90195
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 10372477
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10372477
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.90195
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed