Dimethyl Trisulfide as a Characteristic Odor Associated with Fungating Cancer Wounds

• SHIRASU Mika

  Department of Integrated Biosciences, The University of Tokyo

• NAGAI Shunji

  National Cancer Center, Hospital East

• HAYASHI Ryuichi

  National Cancer Center, Hospital East

• OCHIAI Atsushi

  Department of Integrated Biosciences, The University of Tokyo National Cancer Center, Hospital East

• TOUHARA Kazushige

  Department of Integrated Biosciences, The University of Tokyo

Abstract

Some advanced cancer patients suffer from pungent sulfury malodor. To determine the chemical identity of the odorant, we performed gas chromatography-mass spectrometry-olfactometry analysis of volatiles from fungating cancer wounds. We identified the source of the characteristic smell as dimethyl trisulfide, a compound that is known to be emitted from some vegetables and microorganisms. Controlling the production of dimethyl trisulfide should improve quality of life of patients.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 73 (9), 2117-2120, 2009

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• cancer
• odor
• GC-MS
• olfactometry
• dimethyl trisulfide

Details

• CRID: 1390282681454320512
• NII Article ID: 10027546152
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.90229
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 10373237
• Web Site: http://id.ndl.go.jp/bib/10373237
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10373237
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.90229
• Web Site: https://search.jamas.or.jp/link/ui/2010058097
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed