Luteolin Increases the Expression of GRP94 in HeLa Cells

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Author(s)

Abstract

We found increased expression of GRP94, the 94-kDa glucose-regulated protein, in HeLa cells 24 h after treatment with luteolin. Luteolin increased the levels of GRP94 mRNA and protein, but it did not increase the expression of unfolded protein response (UPR)-regulated genes. In addition, luteolin also enhanced GRP94 promoter activity, suggesting that it enhances the expression of GRP94 at the transcriptional level, not <I>via</I> the UPR signaling pathway.

Journal

  • Bioscience, Biotechnology, and Biochemistry

    Bioscience, Biotechnology, and Biochemistry 73(10), 2341-2344, 2009-10-23

    Japan Society for Bioscience, Biotechnology, and Agrochemistry

References:  13

Codes

  • NII Article ID (NAID)
    10027547259
  • NII NACSIS-CAT ID (NCID)
    AA10824164
  • Text Lang
    ENG
  • Article Type
    NOT
  • ISSN
    09168451
  • NDL Article ID
    10419696
  • NDL Source Classification
    ZR7(科学技術--農林水産--農産) // ZR2(科学技術--生物学--生化学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No.
    Z53-G223
  • Data Source
    CJP  NDL  J-STAGE 
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