Identification and Characterization of an Ecl1-Family Gene in Saccharomyces cerevisiae

  • AZUMA Kenko
    Laboratory of Molecular Microbiology, Graduate School of Bioagricultural Sciences, Nagoya University
  • OHTSUKA Hokuto
    Laboratory of Molecular Microbiology, Graduate School of Bioagricultural Sciences, Nagoya University
  • MITA Satoka
    Laboratory of Molecular Microbiology, Graduate School of Bioagricultural Sciences, Nagoya University
  • MURAKAMI Hiroshi
    Department of Biochemistry and Cell Biology, Graduate School of Medicine, Nagoya City University
  • AIBA Hirofumi
    Laboratory of Molecular Microbiology, Graduate School of Bioagricultural Sciences, Nagoya University

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  • Identification and Characterization of an Ecl1-Family Gene in<i>Saccharomyces cerevisiae</i>

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Abstract

We found that YGR146C of Saccharomyces cerevisiae encodes a functional homolog of Ecl1 that is involved in the chronological lifespan of Schizosaccharomyces pombe. When YGR146C is overexpressed, it extends the viability of wild-type S. cerevisiae cells after entry into the stationary phase, as in the case of Ecl1. We propose that Ecl1 family proteins are novel regulatory factors involved in chronological lifespan among yeasts.

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