A New Lipid Transfer Protein Homolog Identified as an IgE-Binding Antigen from Japanese Cedar Pollen

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  • IBRAHIM Ahmed Ragaa Nour
    Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University
  • KAWAMOTO Seiji
    Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University
  • NISHIMURA Minori
    Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University
  • PAK Syunka
    Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University
  • AKI Tsunehiro
    Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University
  • DIAZ-PERALES Araceli
    Unidad de Bioquimica, Departamento de Biotecnologia, E.T.S. Ingenieros Agronomos, Universidad Politecnica
  • SALCEDO Gabriel
    Unidad de Bioquimica, Departamento de Biotecnologia, E.T.S. Ingenieros Agronomos, Universidad Politecnica
  • ASTURIAS Juan A.
    Research and Development Department, Bial-Aristegui
  • HAYASHI Takaharu
    Takanobashi Central Hospital
  • ONO Kazuhisa
    Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University

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Abstract

Japanese cedar (Cryptomeria japonica) pollen is a major cause of seasonal rhinitis and conjunctivitis in Japan, and an understanding of its full allergen repertoire is prerequisite for the development of future molecular diagnostics and immunotherapeutic strategies. Here we report the identification of a new C. japonica pollen IgE-binding antigen (CJP-8) homologous to lipid transfer proteins (LTPs), a class of plant cross-reactive allergens found in foods, latex, and pollen grains. The cjp-8 cDNA encodes a 165-amino acid polypeptide possessing the conserved eight cysteines characteristic of plant LTP family members. Escherichia coli-expressed recombinant CJP-8 (r-CJP-8) reacted with IgE antibody from Japanese cedar pollinosis patients at a 37.5% frequency (6/16).

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