Polymorphisms in the Human Apolipoprotein E Receptor 2 Gene in Japanese Sporadic Alzheimer's Disease Patients
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- HOSODA Akemi
- Graduate School of Human Life Science, Osaka City University
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- INOUE Takashi
- Laboratory for Developmental Neurobiology, Brain Science Institute
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- MAO Chang C.
- Center for Advanced Genome Research, Institute of Development, Aging, and Cancer, Tohoku University
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- JEONG Young-Hee
- Graduate School of Human Life Science, Osaka City University
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- YAMAGISHI Azumi
- Graduate School of Human Life Science, Osaka City University
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- YE Mingjuan
- Graduate School of Human Life Science, Osaka City University
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- YAMAMOTO Tokuo
- Center for Advanced Genome Research, Institute of Development, Aging, and Cancer, Tohoku University
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- KIM Dong-Ho
- Graduate School of Human Life Science, Osaka City University
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- SAEKI Shigeru
- Graduate School of Human Life Science, Osaka City University
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Abstract
Apolipoprotein E (apoE) polymorphism is associated with onset of Alzheimer’s disease (AD). We found seven polymorphisms in apoE receptor 2 (ApoER2), an apoE-binding receptor, in Japanese sporadic AD patients, but no association of ApoER2 polymorphisms with AD. We consider that the functions of ApoER2 in the brain may be compensated for by those of other apoE-binding receptors such as VLDL receptor.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 74 (3), 677-679, 2010
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Details 詳細情報について
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- CRID
- 1390282681456778880
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- NII Article ID
- 10027553282
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- NII Book ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 10636773
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed