Effects of a Fermented Barley Extract on Subjects with Slightly High Serum Uric Acid or Mild Hyperuricemia
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- HOKAZONO Hideki
- Research Laboratory, Sanwa Shurui Co., Ltd. Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University
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- OMORI Toshiro
- Research Laboratory, Sanwa Shurui Co., Ltd.
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- YAMAMOTO Tetsuro
- TTC Co., Ltd.
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- AKAOKA Ieo
- Chiyodahoujin Clinic
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- ONO Kazuhisa
- Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University
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Abstract
The uric acid-lowering effect and safety of a fermented barley extract P (FBEP) prepared from barley-shochu distillery by-products were investigated in a randomized, placebo-controlled, parallel-group, double-blinded study. A total of 111 subjects with serum uric acid levels of 6.0–7.9 mg/dl were provided with either a drink containing 2 g/d of FBEP (test group) or a placebo drink. After 12 weeks, the serum uric acid levels changed by −0.21±0.56 mg/dl in the test group, showing a significant decrease in comparison to those of the placebo group (+0.02±0.54 mg/dl). Additionally, the uric acid clearance in the test group showed a tendency to increase after 12 weeks more than in the placebo group (p=0.054). No abnormalities in the physical and clinical tests were observed, and no adverse diagnostic findings were attributed to the intake of the test meal. These results demonstrated the benefits and safety of the FBEP treatment to subjects with slightly high serum uric acid or mild hyperuricemia.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 74 (4), 828-834, 2010
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Details 詳細情報について
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- CRID
- 1390282681455497984
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- NII Article ID
- 10027554080
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- NII Book ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 10656555
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed