The transDSL Ligase Ribozyme Can Utilize Various Forms of Modules to Clamp Its Substrate and Enzyme Units

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  • ISHIKAWA Junya
    Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University
  • ISOMOTO Nana
    Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University
  • FUJITA Yuki
    Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University
  • FURUTA Hiroyuki
    Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University
  • IKAWA Yoshiya
    Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University PRESTO, Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency (JST)

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  • The<i>trans</i>DSL Ligase Ribozyme Can Utilize Various Forms of Modules to Clamp Its Substrate and Enzyme Units

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Abstract

TransDSL is an RNA ligase ribozyme whose enzyme unit joins two RNA fragments constituting a substrate. The enzyme unit recognizes the substrate by means of two clamp modules. We constructed active variants by replacing the original clamp module with various types of interactions. Such flexible modularity would be advantageous in the application of this ribozyme in nanobiotechnology.

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