Search for Kinases Related to Transition of Growth Polarity in Fission Yeast

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Author(s)

    • TODA Takashi
    • Laboratory of Cell Regulation, Cancer Research UK, London Research Institute
    • HIRATA Dai
    • Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University

Abstract

In eukaryotes, cell polarity is essential for cell proliferation, differentiation, and development. It is regulated in 3 steps: establishment, maintenance, and transition. Compared to current knowledge of establishment and maintenance, the mechanism regulating the transition of cell polarity is poorly understood. In fission yeast during the G2 phase, growth polarity undergoes a dramatic transition, from monopolar to bipolar growth (termed NETO: new end take off). In this study, we screened systematically for protein kinases related to NETO using a genome-wide kinase deletion library. Analysis of these deletions suggested that 35 and 2 kinases had a putative positive and a negative role, respectively, in NETO. Moreover, 5 kinases were required for NETO-delay in the G1-arrested <I>cdc10</I> mutant. These results suggest that many signaling pathways are involved in the regulation of NETO.

Journal

  • Bioscience, Biotechnology, and Biochemistry

    Bioscience, Biotechnology, and Biochemistry 74(5), 1129-1133, 2010-05-23

    Japan Society for Bioscience, Biotechnology, and Agrochemistry

References:  48

Codes

  • NII Article ID (NAID)
    10027555741
  • NII NACSIS-CAT ID (NCID)
    AA10824164
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    09168451
  • NDL Article ID
    10689117
  • NDL Source Classification
    ZR7(科学技術--農林水産--農産) // ZR2(科学技術--生物学--生化学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No.
    Z53-G223
  • Data Source
    CJP  NDL  J-STAGE 
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