Effect of sesame lignans on TNF-α-induced expression of adhesion molecules in endothelial cells
-
- MOCHIZUKI Mika
- Department of Health and Nutrition, Faculty of Psychological and Physical Science, Aichi Gakuin University Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University
-
- TSUCHIE Yoshikazu
- Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University
-
- YAMADA Naruomi
- Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University
-
- MIYAKE Yoshiaki
- Faculty of Human Wellness, Tokaigakuen University
-
- OSAWA Toshihiko
- Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University
書誌事項
- タイトル別名
-
- Effect of Sesame Lignans on TNF-.ALPHA.-Induced Expression of Adhesion Molecules in Endothelial Cells
- Effect of sesame lignans on TNF a induced expression of adhesion molecules in endothelial cells
この論文をさがす
抄録
The expression of cell adhesion molecules (CAMs) has been implicated as one of the most important causes of the development of inflammatory diseases such as atherosclerosis, and, it is speculated that the prevention of it is an effective approach to the control of atherosclerosis. In the present study, we investigated the effect of sesame lignans on the expression of CAMs in human umbilical vein endothelial cells (HUVECs) induced by tumor necrosis factor-α (TNF-α). Based on cell-ELISA analysis, we found that sesaminol-6-catechol downregulated the TNF-α-induced expression of CAMs in a dose-dependent manner. Moreover, these inhibitory effects were caused to be drastically exerted by downregulating the CAM proteins in TNF-α-activated HUVECs at transcriptional level. This suggests, that sesaminol-6-catehcol suppresses the expression of CAMs, and may be an active component of sesame lignans.
収録刊行物
-
- Bioscience, Biotechnology, and Biochemistry
-
Bioscience, Biotechnology, and Biochemistry 74 (8), 1539-1544, 2010
公益社団法人 日本農芸化学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001206477282432
-
- NII論文ID
- 10027557884
-
- NII書誌ID
- AA10824164
-
- ISSN
- 13476947
- 09168451
-
- NDL書誌ID
- 10836376
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可