Agarwood Induced Laxative Effects<i>via</i>Acetylcholine Receptors on Loperamide-Induced Constipation in Mice

• KAKINO Mamoru

  Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University

• IZUTA Hiroshi

  Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University

• ITO Tetsuro

  Department of Bioactive Molecules, Pharmacognosy, Gifu Pharmaceutical University

• TSURUMA Kazuhiro

  Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University

• ARAKI Yoko

  Nagara Research Center, API Co., Ltd.

• SHIMAZAWA Masamitsu

  Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University

• OYAMA Masayoshi

  Department of Bioactive Molecules, Pharmacognosy, Gifu Pharmaceutical University

• IINUMA Munekazu

  Department of Bioactive Molecules, Pharmacognosy, Gifu Pharmaceutical University

• HARA Hideaki

  Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University

書誌事項

タイトル別名

• Agarwood Induced Laxative Effects via Acetylcholine Receptors on Loperamide-Induced Constipation in Mice

抄録

Agarwood (Aquilaria sinensis, Aquilaria crasna) is well known as an incense in the oriental region such as Thailand, Taiwan, and Cambodia, and is used as a digestive in traditional medicine. We investigated the laxative effects and mechanism of agarwood leaves extracted with ethanol (EEA-1, Aquilaria sinensis; EEA-2, Aquilaria crasna). EEA-1, EEA-2, the main constituents of EEAs (mangiferin, and genkwanin-5-O-primeveroside), and senna increased the frequency and weight of stools in loperamide-induced constipation model mice. EEA-1 and EEA-2 did not induce diarrhea as a side effect, but senna induced severe diarrhea. EEA-1 and senna increased gastro-intestinal (GI) transit in the model mice. EEA-1, but not senna, also increased the intestinal tension of isolated jejunum and ileum in guinea pigs, and the tension increase was blocked by atropine, a muscarinic receptor antagonist, but not by other inhibitors (granicetron, pyrilamine, or bradykinin-antagonist peptide). Furthermore, the increase in frequency and weight of stools induced by EEA-1 were blocked by pre-administration of atropine in the model mice. These findings indicate that EEAs exerted a laxative effect via acetylcholine receptors in the mouse constipation model.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 74 (8), 1550-1555, 2010

  公益社団法人 日本農芸化学会

キーワード

• agarwood
• <I>Aquilaria crasna</I>
• <I>Aquilaria sinensis</I>
• constipation
• laxative effect

詳細情報

• CRID: 1390001206477285248
• NII論文ID: 10027557930
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.100122
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 10836390
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10836390
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.100122
• Web Site: https://search.jamas.or.jp/link/ui/2011118889
• 本文言語コード: en
• データソース種別:
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  • NDL
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• 抄録ライセンスフラグ: 使用不可