精子の capacitation  [in Japanese] Sperm Capacitation  [in Japanese]

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Author(s)

    • 鈴木 達也 SUZUKI Tatsuya
    • 自治医科大学医学部産科婦人科 Department of Obstetrics & Gynecology, School of Medicine, Jichi Medical University
    • 鈴木 光明 SUZUKI Mitsuaki
    • 自治医科大学医学部産科婦人科 Department of Obstetrics & Gynecology, School of Medicine, Jichi Medical University

Abstract

哺乳動物において射出精子は,透明帯との結合,先体反応および卵子との受精のために雌性生殖路内で複雑な生理学的,機能的変化をとげねばならない.この精子が受精可能となる変化を受精能獲得(capacitation)と呼ぶ.capacitationを完了した精子は,透明帯を貫通するための特殊な鞭毛運動である超活性化(hyperactivation)と呼ばれる変化を示す.またcapacitationの過程で,精子表面や精子細胞膜の変化,Ca <sup>2+</sup>やHCO<sub>3</sub><sup>–</sup>イオンの変化,アデニル酸シクラーゼ/cAMP/PKA経路そして精子タンパク質リン酸化の変化を起こす.将来的に,詳細なcapacitationのメカニズムの解明により男性不妊症における精子機能検査法や男性不妊治療法を開発できるかもしれない.<br>

In mammals, ejaculated sperm must undergo complicated physiological and functional changes as they traverse the female reproductive tract before they can bind to the zona pellucida, undergo the acrosome reaction, and fertilize the egg. The preparatory changes are collectively referred to as capacitation. Capacitated sperm show hyperactivation, which is a specialized movement of the sperm flagellum that creates the propulsive force for the penetration of the zona pellucida. Changes in sperm associated with capacitation include alterations in surface properties, plasma membrane properties, ionic metabolism, cyclic nucleotide metabolism and protein phosphorylation. Elucidation of the detailed mechanism of capacitation would enable the development of the sperm function assay and the treatment of male infertility.<br>

Journal

  • Journal of Mammalian Ova Research

    Journal of Mammalian Ova Research 27(4), 166-175, 2010-10-01

    JAPANESE SOCIETY OF OVA RESEARCH

References:  67

Codes

  • NII Article ID (NAID)
    10027595255
  • NII NACSIS-CAT ID (NCID)
    AN10548943
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    13417738
  • NDL Article ID
    10893920
  • NDL Source Classification
    ZR4(科学技術--生物学--動物)
  • NDL Call No.
    Z18-1673
  • Data Source
    CJP  NDL  J-STAGE  JASI 
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