耳下腺に生じたHER-2蛋白陽性唾液腺導管癌例  [in Japanese] A Case of Parotid Gland Salivary Duct Carcinoma with HER-2 Protein Overexpression  [in Japanese]

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Author(s)

Abstract

Salivary duct carcinoma (SDC), a rare aggressive salivary gland tumor with poor prognosis first described by Kleinsasser et al. in 1968, histologically resembles invasive mammary ductal carcinoma.<br> A 68-year-old man with painful left parotid swelling and left facial nerve paralysis underwent extended total parotidectomy, ipsilateral modified neck dissection, and postoperative radiotherapy of 50 Gy.<br> Histopathological examination showed cribriform and papillary intraductal growth and comedonecrosis, yielding a diagnosis of parotid gland SDC. Immunohistochemistry showed strong complete membrane staining for human epidermal growth factor receptor 2 (HER-2).<br> HER-2 protein overexpression is reported to be associated with early distant breast cancer metastasis causing its dismal prognosis. Given studies correlating HER-2 protein expression with poor SDC prognosis, further studies are expected to produce biological therapy for SDC targeting this molecule.<br>

Journal

  • Practica Oto-Rhino-Laryngologica

    Practica Oto-Rhino-Laryngologica 104(1), 33-38, 2011-01-01

    The Society of Practical Otolaryngology

References:  18

Codes

  • NII Article ID (NAID)
    10027626262
  • NII NACSIS-CAT ID (NCID)
    AN00107089
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    00326313
  • NDL Article ID
    10961260
  • NDL Source Classification
    ZS43(科学技術--医学--耳鼻咽喉科学)
  • NDL Call No.
    Z19-421
  • Data Source
    CJP  NDL  J-STAGE 
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