Metastatic renal cell carcinoma complicated with diffuse alveolar hemorrhage: a rare adverse effect of sunitinib Metastatic renal cell carcinoma complicated with diffuse alveolar hemorrhage : a rare adverse effect of sunitinib

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Abstract

金沢大学附属病院がん高度先進治療センターWe report the case of a 67-year-old man with metastatic papillary renal cell carcinoma (RCC) who developed bloody sputum after the administration of sunitinib. Chest computed tomography revealed diffuse ground-glass opacity lesions, and bloody bronchoalveolar lavage fluid was obtained by flexible bronchoscopy. The abnormal shadows promptly regressed after withdrawal of sunitinib. In four cycles of sunitinib treatment, he suffered from controllable diffuse alveolar hemorrhage. Finally, he died of respiratory failure 8 months after onset. This is the first case report of diffuse alveolar hemorrhage as an adverse effect of sunitinib in metastatic papillary RCC. Care should be taken with pulmonary hemorrhage in the use of anti-angiogenesis agents in not only squamous cell lung cancer, but also metastatic lung tumors. © 2010 Japan Society of Clinical Oncology.

Journal

  • International Journal of Clinical Oncology

    International Journal of Clinical Oncology 15(6), 638-641, 2010-12-01

    Springer Verlag (Germany)

References:  18

Codes

  • NII Article ID (NAID)
    10027665563
  • NII NACSIS-CAT ID (NCID)
    AA11086579
  • Text Lang
    ENG
  • Article Type
    NOT
  • ISSN
    13419625
  • Data Source
    CJP  IR 
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