The Inhibitory Effects of Catechins on Biofilm Formation by the Periodontopathogenic Bacterium,<i>Eikenella corrodens</i>

• MATSUNAGA Tetsuro

  Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University

• NAKAHARA Aya

  Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University

• MINNATUL Karim M.

  Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University Department of Biothechnology and Genetic Engineering, Islamic University

• NOIRI Yuichiro

  Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry

• EBISU Shigeyuki

  Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry

• KATO Akio

  Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University

• AZAKAMI Hiroyuki

  Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University

書誌事項

タイトル別名

• The Inhibitory Effects of Catechins on Biofilm Formation by the Periodontopathogenic Bacterium, Eikenella corrodens

抄録

Eikenella corrodens is a periodontopathogenic bacterium that forms biofilm even by itself. In this study, we investigated the inhibitory effects of catechins on E. corrodens biofilm formation. Biofilm formation was inhibited by the addition of 1 mM of the catechins with the pyrogallol-type B-ring and/or the galloyl group. The catechins with the galloyl group were effective at smaller doses than those with only the pyrogallol-type B-ring. An inhibitory effect was observed even when these catechins and gallic acid were added at sub-minimal inhibitory concentration (MIC) or at concentrations that showed no bactericidal effect. These results suggest that some catechins at sub-MIC might inhibit biofilm formation. No inhibitory effect of catechins at sub-MIC on biofilm formation was observed in the luxS deletion mutant. Our studies suggest that some species of catechins with the galloyl group affect autoinducer 2-mediated quorum sensing and thereby inhibit biofilm formation by E. corrodens.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 74 (12), 2445-2450, 2010

  公益社団法人 日本農芸化学会

キーワード

• biofilm
• catechin
• periodontal disease

詳細情報

• CRID: 1390282681455811840
• NII論文ID: 10027728071
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.100499
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 10928538
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10928538
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.100499
• Web Site: https://search.jamas.or.jp/link/ui/2011287537
• 本文言語コード: en
• データソース種別:
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  • NDL
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  • CiNii Articles
  • KAKEN
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