Genetic Polymorphisme of FCGRT Encoding FcRn in a Japanese Population and Their Functional Analysis

• ISHII-WATABE Akiko

  Division of Biological Chemistry and Biologicals, National Institute of Health Sciences

• SAITO Yoshiro

  Project Team for Pharmacogenetics, National Institute of Health Sciences Division of Medicinal Safety Sciences, National Institute of Health Sciences

• SUZUKI Takuo

  Division of Biological Chemistry and Biologicals, National Institute of Health Sciences

• TADA Minoru

  Division of Biological Chemistry and Biologicals, National Institute of Health Sciences

• UKAJI Maho

  Project Team for Pharmacogenetics, National Institute of Health Sciences

• MAEKAWA Keiko

  Project Team for Pharmacogenetics, National Institute of Health Sciences Division of Medicinal Safety Sciences, National Institute of Health Sciences

• KUROSE Kouichi

  Project Team for Pharmacogenetics, National Institute of Health Sciences Division of Medicinal Safety Sciences, National Institute of Health Sciences

• KANIWA Nahoko

  Project Team for Pharmacogenetics, National Institute of Health Sciences Division of Medicinal Safety Sciences, National Institute of Health Sciences

• SAWADA Jun-ichi

  Project Team for Pharmacogenetics, National Institute of Health Sciences Division of Organic Chemistry, National Institute of Health Sciences

• KAWASAKI Nana

  Division of Biological Chemistry and Biologicals, National Institute of Health Sciences

• YAMAGUCHI Teruhide

  Division of Biological Chemistry and Biologicals, National Institute of Health Sciences

• EGUCHI NAKAJIMA Takako

  Gastrointestinal Oncology Division, National Cancer Center Hospital

• KATO Ken

  Gastrointestinal Oncology Division, National Cancer Center Hospital

• YAMADA Yasuhide

  Gastrointestinal Oncology Division, National Cancer Center Hospital

• SHIMADA Yasuhiro

  Gastrointestinal Oncology Division, National Cancer Center Hospital

• YOSHIDA Teruhiko

  Genetics Division, National Cancer Center Research Institute, National Cancer Center

• URA Takashi

  Department of Medical Oncology, Aichi Cancer Center Hospital

• SAITO Miyuki

  Department of Medical Oncology, Aichi Cancer Center Hospital

• MURO Kei

  Department of Medical Oncology, Aichi Cancer Center Hospital

• DOI Toshihiko

  Division of Gastrointestinal Oncology/Digestive Endoscopy, National Cancer Center Hospital East

• FUSE Nozomu

  Division of Gastrointestinal Oncology/Digestive Endoscopy, National Cancer Center Hospital East

• YOSHINO Takayuki

  Division of Gastrointestinal Oncology/Digestive Endoscopy, National Cancer Center Hospital East

• OHTSU Atsushi

  Division of Gastrointestinal Oncology/Digestive Endoscopy, National Cancer Center Hospital East Director of Research Center for Innovative Oncology, National Cancer Center Hospital East

• SAIJO Nagahiro

  Deputy Director, National Cancer Center Hospital East

• HAMAGUCHI Tetsuya

  Gastrointestinal Oncology Division, National Cancer Center Hospital

• OKUDA Haruhiro

  Project Team for Pharmacogenetics, National Institute of Health Sciences Division of Organic Chemistry, National Institute of Health Sciences

• MATSUMURA Yasuhiro

  Investigative Treatment Division, National Cancer Center Hospital East

書誌事項

タイトル別名

• Genetic Polymorphisms of FCGRT Encoding FcRn in a Japanese Population and Their Functional Analysis

抄録

  Neonatal Fc receptor (FcRn) plays an important role in regulating IgG homeostasis in the body. Changes in FcRn expression levels or activity caused by genetic polymorphisms of FCGRT, which encodes FcRn, may lead to interindividual differences in pharmacokinetics of therapeutic antibodies. In this study, we sequenced the 5′-flanking region, all exons and their flanking regions of FCGRT from 126 Japanese subjects. Thirty-three genetic variations, including 17 novel ones, were found. Of these, two novel non-synonymous variations, 629G>A (R210Q) and 889T>A (S297T), were found as heterozygous variations. We next assessed the functional significance of the two novel non-synonymous variations by expressing wild-type and variant proteins in HeLa cells. Both variant proteins showed similar intracellular localization as well as antibody recycling efficiencies. These results suggested that at least no common functional polymorphic site with amino acid change was present in the FCGRT of our Japanese population.<br>

収録刊行物

• Ｄｒｕｇ　Ｍｅｔａｂｏｌｉｓｍ　ａｎｄ　Ｐｈａｒｍａｃｏｋｉｎｅｔｉｃｓ

  Ｄｒｕｇ　Ｍｅｔａｂｏｌｉｓｍ　ａｎｄ　Ｐｈａｒｍａｃｏｋｉｎｅｔｉｃｓ 25 (6), 578-587, 2010

  日本薬物動態学会

キーワード

• <i>FCGRT</i>
• neonatal Fc receptor (FcRn)
• genetic polymorphism
• novel non-synonymous variation

詳細情報

• CRID: 1390001205178765952
• NII論文ID: 10027743901
• NII書誌ID: AA1162652X
• DOI: 10.2133/dmpk.dmpk-10-rg-067
• COI: 1:CAS:528:DC%2BC3MXislGju7Y%3D
• ISSN: 18800920
• ISSN: 13474367
• PubMed: 20930418
• Web Site: http://api.elsevier.com/content/article/PII:S1347436715300719?httpAccept=text/xml
• Web Site: http://api.elsevier.com/content/article/PII:S1347436715300719?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2011287560
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可