The Cannabinoid 1-Receptor Silent Antagonist O-2050 Attenuates Preference for High-Fat Diet and Activated Astrocytes in Mice

DOI Web Site 被引用文献2件 参考文献26件
  • Higuchi Sei
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
  • Irie Keiichi
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan Advanced Materials Institute, Fukuoka University, Japan
  • Mishima Shohei
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
  • Araki Maiko
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
  • Ohji Makiko
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
  • Shirakawa Atsunori
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
  • Akitake Yoshiharu
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan Advanced Materials Institute, Fukuoka University, Japan
  • Matsuyama Kiyoshi
    Department of Chemical Engineering, Faculty of Engineering, Fukuoka University, Japan
  • Mishima Kenji
    Department of Chemical Engineering, Faculty of Engineering, Fukuoka University, Japan
  • Mishima Kenichi
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan Advanced Materials Institute, Fukuoka University, Japan
  • Iwasaki Katsunori
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan Advanced Materials Institute, Fukuoka University, Japan
  • Fujiwara Michihiro
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan

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Endocannabinoids have been shown to activate reward-related feeding and to promote astrocytic differentiation. We investigated whether high-fat diet (HFD) intake produced a preference for HFD via an endocannabinoid-dependent mechanism. In the conditioned place preference test, the 2-week HFD–intake group showed preference for HFD and had increased expression of a marker for reactive astrocytes, glial fibrillary acid protein (GFAP), in the hypothalamus. The cannabinoid CB1–receptor antagonist O-2050 reduced the preference for HFD and expression of GFAP in the hypothalamus. These results suggested that HFD intake led to the development of a preference for HFD via astrocytic CB1 receptors in the hypothalamus.

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