皮膚の炎症における細胞接着分子の役割  [in Japanese] The role of adhesion molecules in cutaneous inflammation  [in Japanese]

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Author(s)

    • 門野 岳史 KADONO Takafumi
    • 東京大学大学院医学系研究科皮膚科学 Department of Dermatology, Graduate School of Medicine, University of Tokyo

Abstract

  血球細胞はまず皮膚の血管内皮細胞によって捕獲(capture)され,血管に沿って転がり(rolling),固着する(firm adhesion).その後,血管内皮細胞を通り抜け(transmigration),血管外へと遊出し(diapedesis),皮膚へと浸潤する.これらの過程には様々な細胞接着分子が重要であり,例えばcaptureおよびrollingはセレクチンファミリーによって主に制御される.セレクチンファミリーはL-selectin, P-selectin, E-selectinよりなり,これらの分子の阻害により皮膚の炎症が減弱する.Firm adhesionにはインテグリンファミリーが重要であり,その主なものとしてβ2 integrinとそのリガンドであるICAM-1およびα4 integrinとそのリガンドであるVCAM-1がある.これらの分子の阻害によっても皮膚の炎症は減弱する.Transmigrationおよびdiapedesisに関与する分子に関しても,PECAM-1, CD99, JAMの阻害により皮膚の炎症が改善した報告がみられている.今後,これら様々な細胞接着因子を抑えることにより,皮膚の炎症を制御することが期待される.<br>

  Adhesion molecules are critical for leukocytes migration to the skin. Leukocytes must first be captured or tethered from the flowing blood allowing them to roll along the skin vessels. Leukocytes are activated by chemoattractants, which results in firm adhesion and arrest and ultimately transendothelial migration into the tissue. Selectin family which consists of L-selectin, P-selectin, E-selectin is critical for capture and rolling. Deficiency of these molecules leads to the diminution of cutaneous inflammation. Firm adhesion is governed by β2 integrin and α4 integrin. Inhibition of β2 integrin and its ligand ICAM-1 also reduce cutaneous inflammation. Similarly, blocking of α4 integrin and its ligand VCAM-1 alleviate inflammation of the skin. Transmigration and diapedesis are mediated by various molecules such as PECAM-1, CD99, and JAM, whose inhibition also leads to amelioration of skin inflammation. Manipulating adhesion molecules might lead to novel therapy to treat dermatitis by controlling leukocytes migration into cutaneous sites of inflammation.<br>

Journal

  • Japanese Journal of Clinical Immunology

    Japanese Journal of Clinical Immunology 33(5), 242-248, 2010-10-31

    The Japan Society for Clinical Immunology

References:  44

Codes

  • NII Article ID (NAID)
    10027753863
  • NII NACSIS-CAT ID (NCID)
    AN00357971
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    09114300
  • Data Source
    CJP  J-STAGE 
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