mtGFP-Tgマウス組織におけるミトコンドリア形態学的解析 Global Imaging of Mitochondrial Morphology in Tissues Using Transgenic Mice Expressing Mitochondrially Targeted Enhanced Green Fluorescent Protein

Access this Article

Author(s)

Abstract

The most common approach to analyzing the static morphology of mitochondria involves staining by antibodies or fluorescent dyes specific for mitochondrial components. In this study, we present a new approach using transgenic (Tg) mice, mtGFP-Tg mice, which exclusively express EGFP in the mitochondrial matrix. This Tg strain enables the rapid and easy observation of mitochondria in many kinds of tissues of interest. Recently, many reports have indicated that mitochondrial abnormalities and disease phenotypes are closely associated. mtGFP-Tg mice will be very useful in demonstrating this association, via the use of hybrids of mtGFP-Tg mice and well-established model mice for human diseases.<br>

Journal

  • Experimental Animals

    Experimental Animals 59(1), 99-103, 2010-01-01

    Japanese Association for Laboratory Animal Science

References:  16

Codes

  • NII Article ID (NAID)
    10027852751
  • NII NACSIS-CAT ID (NCID)
    AA11032321
  • Text Lang
    ENG
  • Article Type
    NOT
  • ISSN
    13411357
  • NDL Article ID
    10811102
  • NDL Source Classification
    ZS7(科学技術--医学)
  • NDL Call No.
    Z54-H752
  • Data Source
    CJP  NDL  J-STAGE 
Page Top