Global Imaging of Mitochondrial Morphology in Tissues Using Transgenic Mice Expressing Mitochondrially Targeted Enhanced Green Fluorescent Protein

DOI Web Site Web Site 被引用文献3件 参考文献27件
  • SHITARA Hiroshi
    Laboratory of Mouse Models for Human Heritable Diseases, The Tokyo Metropolitan Institute of Medical Science
  • SHIMANUKI Midori
    Laboratory of Mouse Models for Human Heritable Diseases, The Tokyo Metropolitan Institute of Medical Science Graduate School of Life and Environmental Sciences, University of Tsukuba
  • HAYASHI Jun-Ichi
    Graduate School of Life and Environmental Sciences, University of Tsukuba
  • YONEKAWA Hiromichi
    Laboratory of Mouse Models for Human Heritable Diseases, The Tokyo Metropolitan Institute of Medical Science Graduate School of Life and Environmental Sciences, University of Tsukuba

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抄録

The most common approach to analyzing the static morphology of mitochondria involves staining by antibodies or fluorescent dyes specific for mitochondrial components. In this study, we present a new approach using transgenic (Tg) mice, mtGFP-Tg mice, which exclusively express EGFP in the mitochondrial matrix. This Tg strain enables the rapid and easy observation of mitochondria in many kinds of tissues of interest. Recently, many reports have indicated that mitochondrial abnormalities and disease phenotypes are closely associated. mtGFP-Tg mice will be very useful in demonstrating this association, via the use of hybrids of mtGFP-Tg mice and well-established model mice for human diseases.<br>

収録刊行物

  • Experimental Animals

    Experimental Animals 59 (1), 99-103, 2010

    公益社団法人 日本実験動物学会

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