マウス第12染色体上の成長QTL Pbwg12を導入したコンジェニック系統の樹立と特徴解析 Development and Characterization of a Congenic Strain Carrying Pbwg12, a Growth QTL on Mouse Chromosome 12

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Author(s)

    • 石川 明 ISHIKAWA Akira
    • Laboratory of Animal Genetics, Division of Applied Genetics and Physiology, Graduate School of Bioagricultural Sciences, Nagoya University
    • 李 春 LI Chun
    • Laboratory of Animal Genetics, Division of Applied Genetics and Physiology, Graduate School of Bioagricultural Sciences, Nagoya University

Abstract

In previous genome-wide QTL studies, <i>Pbwg12</i> on mouse chromosome 12 was discovered in a gene pool of wild <i>Mus musculus</i> castaneus mice. <i>Pbwg12</i> does not have a main effect but has an epistatic interaction effect on body weight after birth. In this study, we developed a congenic strain, named B6.Cg-<i>Pbwg12</i>, with an approximately 59-Mb wild-derived genomic region harboring <i>Pbwg12</i>, by recurrent backcrossing to C57BL/6J. A phenotypic comparison between B6.Cg-<i>Pbwg12</i> and C57BL/6J revealed that <i>Pbwg12</i> does not have any main effects on body weight at 1-10 weeks of age but has a main effect on body weight gain at 6-10 weeks. A new QTL with a male-specific effect on kidney weight was discovered within the introgressed region.<br>

Journal

  • Experimental Animals

    Experimental Animals 59(1), 109-113, 2010-01-01

    Japanese Association for Laboratory Animal Science

References:  11

Codes

  • NII Article ID (NAID)
    10027852777
  • NII NACSIS-CAT ID (NCID)
    AA11032321
  • Text Lang
    ENG
  • Article Type
    NOT
  • ISSN
    13411357
  • NDL Article ID
    10811140
  • NDL Source Classification
    ZS7(科学技術--医学)
  • NDL Call No.
    Z54-H752
  • Data Source
    CJP  NDL  J-STAGE 
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