沖縄県における亜急性硬化性全脳炎の発生状況 (1977-2005)  [in Japanese] Epidemiology of Subacute Sclerosing Panencephalitis in Okinawa, Japan (1977-2005)  [in Japanese]

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Abstract

 1977年から2005年までに沖縄県で発生した亜急性硬化性全脳炎 (SSPE) は22例 (男性16例, 女性6例) であった. 1999年時調査より6例増加していた. 2000年から2005年までの発生頻度は, 人口100万人当たり年平均0.75人であった. 本県では予防接種率が低く (40~71%), 2001年まで麻疹の流行を繰り返していた. その際, 低年齢での罹患が多いことが未だにSSPEが発生している要因の一つだと思われた. また, 1990年から1991年までの麻疹罹患者から10例のSSPEが発生していた. 流行するウイルスの神経病原性にも関連があると思われた.

  The epidemiology of subacute sclerosing panencephalitis (SSPE) has changed since the introduction of measles immunization in 1970's. We studied the incidence of SSPE in Okinawa. There were 22 cases (16 males and 6 females) of SSPE from 1977 to 2005 in Okinawa. The incidence was 0.63 per million population per year from 1977 to 1986, 0 from 1987 to 1993, 1.17 from 1994 to 1999 and 0.75 from 2000 to 2005. Twenty-one SSPE patients had a history of non-immunized measles and 19 of them (90%) had measles infection under 2 years of age. There were measles epidemic every 2-5 years in Okinawa. Ten of 21 cases contracted measles in 1990-1991. The percentage of patients with measles infection under 2 years of age during measles epidemics ranged from 46% to 56%. Early measles infection (under 2 years of age) is a risk factor for SSPE. Routine measles immunization to prevent measles infection is very important for the prevention of SSPE.

Journal

  • NO TO HATTATSU

    NO TO HATTATSU 42(6), 427-431, 2010-11-01

    The Japanese Society of Child Neurology

References:  16

Codes

  • NII Article ID (NAID)
    10027865478
  • NII NACSIS-CAT ID (NCID)
    AN0020232X
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    00290831
  • Data Source
    CJP  J-STAGE 
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