ポストイニシエーション期に投与した高温高圧処理ニンニク粉末による1,2-ジメチルヒドラジン誘発ラット大腸前がん病変抑制作用  [in Japanese] Effects of High Temperature- and Pressure-Treated Garlic on 1,2-Dimethylhydrazine-Induced Premalignant Lesions in the Rat Colorectum at the Post-Initiation Stage  [in Japanese]

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Abstract

ニンニクの新たな処理法である高温高圧処理したニンニク(HTPG)を用い,1,2-ジメチルヒドラジン誘発ラット大腸前がん病変形成に対するポストイニシエーション期投与の影響を検討した.その結果,HTPGの3%混餌群では大腸前がん病変であるムチン枯渇巣(MDF)形成を有意に抑制した.また,血液学的および血漿生化学的所見ではHTPG投与による影響はほとんどみられなかった.我々はこれまでにHTPGがイニシエーション期投与によってもMDF形成を有意に抑制することや抗酸化能が増強することを報告しており,これらの結果と考え合わせるHTPGは健康食品素材として有用かもしれない.

We examined the effects of high temperatureand pressure-treated garlic (HTPG), which has enhanced antioxidative activity, on 1,2-dimethylhydrazine (DMH)-induced mucin-depleted foci (MDF), as premalignant lesions, in the rat colorectum at the post-initiation stage. Male F344 rats (5 weeks old) were injected s.c. with DMH (40mg/kg, once weekly for 2 weeks). Rats were fed basal diet or experimental diets containing 1% or 3% HTPG for 6 weeks, starting 1 week after the last injection of DMH. At sacrifice, the number of MDF in the 3% HTPG diet group was significantly lower than that in the basal diet group. In addition, we also studied the influence of 3% HTPG diet ingestion. Rats were fed basal diet or 3% HTPG diet under the above conditions without DMH treatment. The 3% HTPG diet did not affect most hematological and plasma biochemical parameters. These results, combined with our previous work (APJCP, 2009), suggest that HTPG may be useful as a health supplement.

Journal

  • Nippon Shokuhin Kagaku Kogaku Kaishi

    Nippon Shokuhin Kagaku Kogaku Kaishi 58(3), 131-135, 2011-03-15

    Japanese Society for Food Science and Technology

References:  15

Codes

  • NII Article ID (NAID)
    10027868993
  • NII NACSIS-CAT ID (NCID)
    AN10467499
  • Text Lang
    JPN
  • Article Type
    NOT
  • ISSN
    1341027X
  • NDL Article ID
    10998959
  • NDL Source Classification
    ZP34(科学技術--食品工学・工業)
  • NDL Call No.
    Z17-126
  • Data Source
    CJP  NDL  J-STAGE  JASI 
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